Human HRD and HRR Gene Mutation Test Kit

The homologous recombination repair (HRR) pathway is responsible for repairing DNA double-stranded breaks in mammalian cells. Deficiency of the HRR pathway is common in many cancers and is recognized as apotent tumorigenic driver in several cancers, including ovarian, breast, prostate, and pancreatic cancer. 

Homologous recombination deficiency (HRD) has been demonstrated to be sensitive to both platinum-based chemotherapy and poly ADP-ribose polymerase inhibitors (PARPi), especially in ovarian and breast cancer.

Key Features and Benefits

• Comprehensive Coverage

  Provides the information on the HRD score andmutations in 66 HRR genes, including SNVs, Indels, CNV loss of some genes, and large genomic rearrangement (LGR) of BRCA1/2

• Innovative Design

  Combines WGS and a SNP panel for dual platform joint detection of HRD score, enhancing the stability of detection results

  Utilizes SNPs specifically chosen for the Asian population to improve the detection efficiency

• Patent Algorithm

  Requires as low as 20% tumor presence, expanding test opportunities for more patients 

  Achieves 96% consistency between HRD score and BRCAness

Gene List

Specifications